Synthesis and Wound Healing Properties of PAN/NO, a polymeric diazeniumdiolate,
and PROLI/NO , an Ultrafast NO Donor
NO has multiple functions in wound healing. We have
developed NO-releasing polymers
such as the poly(acrylonitrile)/NO adduct (PAN/NO). This material has proven useful in wound healing applications,
e.g., to reduce neointimal hyperplasia after vascular surgery
(DeRosa et al., 2007). The ultrafast NO donor
similar effects (Kapadia et al., 2008). Interestingly,
PROLI/NO’s beneficial effect was more pronounced in diabetic rats than
in normal animals (Ahanchi et al., 2008).
Synthesis of PAN/NO
and hydrolysis of PROLI/NO, an ultrafast NO donor.
Improved healing of rat
carotid arteries by treating them with PAN/NO during surgery. Arrows show the
extent of neointimal hyperplasia in the untreated vessel two weeks after
the vascular intervention. Note the marked contrast to what was seen in the PAN/NO-treated