PROLI/NO Derivatives
The diazeniumdiolate anion of L-proline, PROLI/NO, spontaneously dissociates under physiological conditions to release nitric oxide with a half-life of 2 s. A minor byproduct of nitric oxide release from PROLI/NO is N-nitrosoproline (NPRO), which has shown no carcinogenic activity in several animal models. Thus, this aspect of innocuous byproduct formation makes PROLI/NO an attractive nitric oxide prodrug from the clinical standpoint.
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