Diazeniumdiolates as prodrugs of both
NO and HNO
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Nitroxyl (HNO), the 1-electron reduced and protonated congener of nitric oxide (NO), has received recent attention as a potential pharmacological agent for the treatment of heart failure and as a preconditioning agent for the mitigation of ischemia-reperfusion injury. Although the potential use of HNO as a pharmacological agent is clear, the high reactivity of HNO compared to NO, especially self-consumption by dimerization, creates extra challenges for HNO detection and quantification.
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We are developing a chemical method for the detection and quantification of HNO
using an aromatic nitroso derivative. The reactions are monitored by HPLC. The synthesis of new nitroxyl (HNO) prodrugs and their corresponding kinetic studies are also performed. Nitric oxide (NO) is an endogenous messenger molecule that is extensively involved in the physiologic regulation of different tissues in the human body.
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Nitric oxide has been shown to have therapeutic potential as a drug. The bis-diazeniumdiolates synthesized have the ability to react with GSH to produce bioactive nitric oxide (NO).
Related Publications
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Wink, D. A.; Miranda, K. M.; Katori, T.; Mancardi, D.; Thomas, D. D.; Ridnour, L.; Espey, M. G.; Feelisch, M.; Colton, C. A.; Fukuto, J. M.; Pagliaro, P.; Kass, D. A.; Paolocci, N. Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.Am. J Physiol Heart Circ. Physiol 2003, 285, H2264-H2276.
